rs12597511

A SNP in the PRSS8 gene on chromosome 16. Its most notable genotype is C;C: normal

Gene
PRSS8
Location
Chr 1631,133,898 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.044% of people
  2. C;TNot ratedslightly higher blood pressureTypical · 0.027% of people
  3. T;TNot ratedslightly higher blood pressureTypical · 0.029% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 44% C;T 27% T;T 29%
  • European ancestry (Utah)C;C 39% C;T 42% T;T 20%
  • Han Chinese (Beijing)C;C 0% C;T 10% T;T 90%
  • Japanese (Tokyo)C;C 0% C;T 19% T;T 81%
  • Yoruba (Nigeria)C;C 88% C;T 12% T;T <1%
  • African ancestry (Southwest US)C;C 77% C;T 19% T;T 4%
  • Chinese (Denver)C;C <1% C;T 17% T;T 82%
  • Gujarati IndianC;C 69% C;T 30% T;T 1%
  • Luhya (Kenya)C;C 82% C;T 17% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 29% C;T 48% T;T 22%
  • Maasai (Kenya)C;C 69% C;T 28% T;T 3%
  • TuscanC;C 32% C;T 51% T;T 17%

Notes

From SNPedia

Notes

rs12597511, a SNP in the serine protease prostasin PRSS8 gene, has been linked to higher blood pressure (and thus risk of hypertension) in a study of healthy subjects. Both African-Americans and European-Americans with rs12597511(C;T) or rs12597511(T;T) genotypes had (slightly) higher systolic and diastolic blood pressure than (C;C) individuals.

Source and license

Adapted from rs12597511 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.