rs12678919

A SNP on chromosome 8. Its most notable genotype is A;G: associated with higher HDL cholesterol

Gene
None listed
Location
Chr 819,986,711 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon on affy axiom dataTypical · 0.083% of people
  2. A;GMost notableGoodassociated with higher HDL cholesterolWorth knowing · 2.016% of people
  3. G;GGoodassociated with higher HDL cholesterolWorth knowing · 2.0<1% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 83% A;G 16% G;G <1%
  • European ancestry (Utah)A;A 81% A;G 16% G;G 4%
  • Han Chinese (Beijing)A;A 82% A;G 18% G;G <1%
  • Japanese (Tokyo)A;A 81% A;G 18% G;G <1%
  • Yoruba (Nigeria)A;A 82% A;G 18% G;G 0%
  • African ancestry (Southwest US)A;A 79% A;G 21% G;G 0%
  • Chinese (Denver)A;A 77% A;G 22% G;G <1%
  • Gujarati IndianA;A 82% A;G 18% G;G 0%
  • Luhya (Kenya)A;A 92% A;G 7% G;G <1%
  • Mexican ancestry (Los Angeles)A;A 90% A;G 10% G;G 0%
  • Maasai (Kenya)A;A 90% A;G 10% G;G 0%
  • TuscanA;A 78% A;G 19% G;G 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

G allele is associated with 2.44mg/dl increase in HDL cholesterol (good cholesterol). Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

Source and license

Adapted from rs12678919 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.