rs12721510

A SNP in the CRH gene on chromosome 8. Its most notable genotype is T;T: Risk for ACTH deficiency

Gene
CRH
Location
Chr 866,178,947 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadRisk for ACTH deficiencyTypical · 0.00% of people
  2. G;GGoodcommon in clinvarTypical · 0.096% of people

SNPedia records rs12721510 on the minus strand: (A;A), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageT;T 0% G;G 96%
  • European ancestry (Utah)T;T 0% G;G 88%
  • Han Chinese (Beijing)T;T 0% G;G 100%
  • Japanese (Tokyo)T;T 0% G;G 99%
  • Yoruba (Nigeria)T;T 0% G;G 100%
  • African ancestry (Southwest US)T;T 0% G;G 98%
  • Mexican ancestry (Los Angeles)T;T 0% G;G 97%
  • Maasai (Kenya)T;T 0% G;G 99%
  • TuscanT;T 0% G;G 87%

Source and license

Adapted from rs12721510 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.