rs12722477
A SNP in the HLA-G gene on chromosome 6. Its most notable genotype is C;C.
- Gene
- HLA-G
- Location
- Chr 629,828,599 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 7 HapMap populations.
- AverageC;C 92%
- European ancestry (Utah)C;C 98%
- Han Chinese (Beijing)C;C 99%
- Japanese (Tokyo)C;C 94%
- Gujarati IndianC;C 99%
- Luhya (Kenya)C;C 98%
- Maasai (Kenya)C;C 58%
- TuscanC;C 98%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs12722477, also known as Leu134Ile, a SNP of the HLA-G gene, was significantly associated with Kawasaki disease (odds ratio 3.23, CI = 1.12-9.32), based on an initial study of 48 cases and a replication study with 44 cases.
Source and license
Adapted from rs12722477 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.