rs12746200

A SNP in the PLA2G4A gene on chromosome 1. Its most notable genotype is G;G: less cardiovascular disease, more colon cancer

Gene
PLA2G4A
Location
Chr 1186,880,054 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormal cardiovascular and colon cancerMinor · 1.087% of people
  2. A;GNot ratedless cardiovascular diseaseMinor · 1.012% of people
  3. G;GMost notableNot ratedless cardiovascular disease, more colon cancerWorth knowing · 2.0<1% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 87% A;G 12% G;G <1%
  • European ancestry (Utah)A;A 84% A;G 16% G;G 0%
  • Han Chinese (Beijing)A;A 93% A;G 7% G;G 0%
  • Japanese (Tokyo)A;A 81% A;G 15% G;G 4%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%
  • African ancestry (Southwest US)A;A 95% A;G 5% G;G 0%
  • Chinese (Denver)A;A 92% A;G 7% G;G <1%
  • Gujarati IndianA;A 80% A;G 18% G;G 2%
  • Mexican ancestry (Los Angeles)A;A 78% A;G 22% G;G 0%
  • Maasai (Kenya)A;A 90% A;G 10% G;G 0%
  • TuscanA;A 81% A;G 19% G;G 0%

Notes

From SNPedia

Notes

Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs.

G;G

Lower cardiovascular disease risk, but possibly more colon cancer

Source and license

Adapted from rs12746200 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.