rs12752888

A SNP in the LOC105378734 gene on chromosome 1. Its most notable genotype is C;C: Faster progression of mild cognitive impairment to Alzheimer’s disease.

Gene
LOC105378734
Location
Chr 154,527,266 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadFaster progression of mild cognitive impairment to Alzheimer’s disease.Minor · 1.05% of people
  2. C;TGoodNormal progression to Alzheimer’s disease from mild cognitive impairment.Minor · 1.027% of people
  3. T;TGoodNormal progression to Alzheimer’s disease from mild cognitive impairment.Minor · 1.067% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 5% C;T 27% T;T 67%
  • European ancestry (Utah)C;C 12% C;T 34% T;T 55%
  • Han Chinese (Beijing)C;C 0% C;T 5% T;T 95%
  • Japanese (Tokyo)C;C 0% C;T 2% T;T 98%
  • Yoruba (Nigeria)C;C 5% C;T 36% T;T 59%
  • African ancestry (Southwest US)C;C 5% C;T 35% T;T 60%
  • Chinese (Denver)C;C 0% C;T 6% T;T 94%
  • Gujarati IndianC;C 3% C;T 41% T;T 56%
  • Luhya (Kenya)C;C 15% C;T 42% T;T 44%
  • Mexican ancestry (Los Angeles)C;C 5% C;T 28% T;T 67%
  • Maasai (Kenya)C;C 9% C;T 40% T;T 51%
  • TuscanC;C 3% C;T 34% T;T 63%

Notes

From SNPedia

Show notes, about 220 words

rs12752888 is a SNP on chromosome 1 upstream of the gene ACOT11. ACOT11 has been associated with obesity and is a member of a family of enzymes that help catalyze the de-esterification of fatty acids. One study used genotyping information from 489 patients with mild cognitive impairment (MCI) from the Vitamin E trial. The GWAS employed used Alzheimer&#8217;s disease progression measured quantitatively from Clinical Dementia Rating-sum of boxes (CRD-SB) scores over time. Additionally, the study utilized information about 200 Alzheimer&#8217;s disease patients, 300 MCI patients, and 200 controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) consortium. Significance was assessed based on the interaction term between genotype and time in a Cox proportional hazards model. rs12752888 was among two SNPs in the GWAS study to reach genome-wide significance in the Vitamin E MCL trial with a false-positive rate of 0.05 adjusting for 1 million SNPs (p < 8.31 &#215; 10^&#8722;9 ). Combining both datasets, rs12752888 reached significance of p = 3.08 x 10^-11. Overall with a hazard rate of 1.78, this suggests that the homozygous recessive genotype contributes to a faster rate of cognitive decline in mild cognitive impaired individuals in their progression to Alzheimer&#8217;s disease.

Source and license

Adapted from rs12752888 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.