rs12770228

A SNP in the C10orf114 gene on chromosome 10. Its most notable genotype is A;A: 2x increased risk for meningioma

Gene
C10orf114
Location
Chr 1021,494,705 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x increased risk for meningiomaWorth knowing · 2.04% of people
  2. A;GBad1.4x increased risk for meningiomaMinor · 1.418% of people
  3. G;GNot ratedNo summary available.Typical · 0.078% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 4% A;G 18% G;G 78%
  • European ancestry (Utah)A;A 11% A;G 40% G;G 50%
  • Han Chinese (Beijing)A;A 0% A;G 2% G;G 98%
  • Japanese (Tokyo)A;A 0% A;G <1% G;G 99%
  • Yoruba (Nigeria)A;A 1% A;G 9% G;G 90%
  • African ancestry (Southwest US)A;A 4% A;G 18% G;G 79%
  • Chinese (Denver)A;A 0% A;G <1% G;G 99%
  • Gujarati IndianA;A 9% A;G 34% G;G 57%
  • Luhya (Kenya)A;A 0% A;G 8% G;G 92%
  • Mexican ancestry (Los Angeles)A;A 3% A;G 28% G;G 69%
  • Maasai (Kenya)A;A <1% A;G 12% G;G 88%
  • TuscanA;A 15% A;G 44% G;G 41%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12770228 is a SNP in a region on ch 10p12.31 designated as the chromosome 10 open reading frame 114 C10orf114; it is just upstream of the MLLT10 gene. A study of ~1,600 patients with meningioma, all of European ancestry, concluded that increased risk for the disease was associated with rs12770228(A) alleles. The odds ratio was 1.37 (CI: 1.18-1.59, p = 4 x 10e-4). A nearby SNP, rs11012732, was also linked to meningioma risk.

Source and license

Adapted from rs12770228 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.