rs13149290

A SNP in the ZNF827 gene on chromosome 4. Its most notable genotype is C;C: Slightly increased risk of developing prostate cancer

Gene
ZNF827
Location
Chr 4145,829,814 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
42%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadSlightly increased risk of developing prostate cancerMinor · 1.537% of people
  2. C;TBadSlightly increased risk of developing prostate cancerMinor · 1.535% of people
  3. T;TGoodNormal risk of developing prostate cancerMinor · 1.028% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 37% C;T 35% T;T 28%
  • European ancestry (Utah)C;C 63% C;T 37% T;T 0%
  • Han Chinese (Beijing)C;C 4% C;T 25% T;T 71%
  • Japanese (Tokyo)C;C 6% C;T 24% T;T 70%
  • Yoruba (Nigeria)C;C 63% C;T 29% T;T 8%
  • African ancestry (Southwest US)C;C 63% C;T 30% T;T 7%
  • Chinese (Denver)C;C 3% C;T 24% T;T 73%
  • Gujarati IndianC;C 28% C;T 48% T;T 25%
  • Luhya (Kenya)C;C 53% C;T 42% T;T 5%
  • Mexican ancestry (Los Angeles)C;C 17% C;T 48% T;T 35%
  • Maasai (Kenya)C;C 51% C;T 43% T;T 6%
  • TuscanC;C 54% C;T 38% T;T 8%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs13149290 is one of seven SNPs found in a combined study of over 1,000 patients to be associated with increased risk for prostate cancer. The risk allele for this SNP is (C); and while the odds ratio was not specifically reported, the probability of false significance (not permuted though) was given as p=2.5 x 10e-5, using a dominant model of risk.

Source and license

Adapted from rs13149290 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.