rs13192841

A SNP on chromosome 6. Its most notable genotype is A;A: somewhat reduced risk (~0.5x) for lupus

Gene
None listed
Location
Chr 6137,646,077 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodsomewhat reduced risk (~0.5x) for lupusWorth knowing · 2.14% of people
  2. A;GGoodsomewhat reduced risk (~0.7x) for lupusWorth knowing · 2.027% of people
  3. G;GBadcommon/normalTypical · 0.069% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 4% A;G 27% G;G 69%
  • European ancestry (Utah)A;A 8% A;G 31% G;G 61%
  • Han Chinese (Beijing)A;A <1% A;G 18% G;G 82%
  • Japanese (Tokyo)A;A <1% A;G 17% G;G 82%
  • Yoruba (Nigeria)A;A 1% A;G 14% G;G 85%
  • African ancestry (Southwest US)A;A 2% A;G 28% G;G 70%
  • Chinese (Denver)A;A 0% A;G 19% G;G 81%
  • Gujarati IndianA;A 14% A;G 44% G;G 41%
  • Luhya (Kenya)A;A 0% A;G 13% G;G 87%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 48% G;G 45%
  • Maasai (Kenya)A;A 1% A;G 23% G;G 75%
  • TuscanA;A 8% A;G 45% G;G 47%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs13192841 is a SNP in an intergenic region of chromosome 6. Three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) were associated with systemic lupus erythematosus (SLE) among individuals of European ancestry in a study of 1,200+ patients. For rs13192841, the minor allele was associated with reduced risk (OR 0.72 CI: 0.62–0.83, p = 7.9 × 10e−6. The authors point out that rs13192841 is a "perfect proxy" for rs10499194, which has a similiar reduced risk for rheumatoid arthritis associated with it's minor allele. An association was found between Systemic lupus erythematosus (SLE) and rs13192841.

A;A

see discussion at rs13192841

A;G

see discussion at rs13192841

Source and license

Adapted from rs13192841 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.