rs13208321

A SNP on chromosome 6. Its most notable genotype is A;A: slight increase in risk for migraine

Gene
None listed
Location
Chr 696,412,478 (GRCh38)
Highest magnitude
1.4Minor
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadslight increase in risk for migraineMinor · 1.414% of people
  2. A;GBadslight increase in risk for migraineMinor · 1.237% of people
  3. G;GGoodcommon/normalTypical · 0.049% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 14% A;G 37% G;G 49%
  • European ancestry (Utah)A;A 4% A;G 33% G;G 63%
  • Han Chinese (Beijing)A;A <1% A;G 15% G;G 85%
  • Japanese (Tokyo)A;A 4% A;G 30% G;G 66%
  • Yoruba (Nigeria)A;A 34% A;G 51% G;G 15%
  • African ancestry (Southwest US)A;A 40% A;G 53% G;G 7%
  • Chinese (Denver)A;A 0% A;G 21% G;G 79%
  • Gujarati IndianA;A 3% A;G 28% G;G 69%
  • Luhya (Kenya)A;A 30% A;G 47% G;G 23%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 39% G;G 60%
  • Maasai (Kenya)A;A 23% A;G 52% G;G 26%
  • TuscanA;A 9% A;G 41% G;G 50%

Notes

From SNPedia

Notes

rs13208321 represents a SNP located in chromosomal region 6q16, potentiallly within the FHL5 gene. The FHL5 gene encodes a transcription factor that regulates cAMP responsive elements CREM and CREB6, which play a role in synaptic plasticity and memory formation. However, it is not known if this is associated in any way with the migraine risk associated with this SNP. A meta-analysis across 29 GWA studies, including a total of 23,285 migraine cases and 95,425 population-matched controls, found a slight increase in risk for migraine associated with rs13208321(A), (OR 1.18, CI:1.13-1.24, p=2.15 × 10e-12).

A;A

see discussion at rs13208321

A;G

see discussion at rs13208321

Source and license

Adapted from rs13208321 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.