rs13208776

A SNP in the SMOC2 gene on chromosome 6. Its most notable genotype is A;A: normal

Gene
SMOC2
Location
Chr 6168,540,944 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.03% of people
  2. A;GNot ratednormalTypical · 0.016% of people
  3. G;GNot ratedhigher risk for generalized vitiligoTypical · 0.082% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 3% A;G 16% G;G 82%
  • European ancestry (Utah)A;A 12% A;G 45% G;G 43%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 9% G;G 91%
  • Chinese (Denver)A;A 0% A;G 4% G;G 96%
  • Gujarati IndianA;A 1% A;G 25% G;G 74%
  • Luhya (Kenya)A;A 0% A;G 5% G;G 96%
  • Mexican ancestry (Los Angeles)A;A 3% A;G 26% G;G 71%
  • Maasai (Kenya)A;A <1% A;G 22% G;G 77%
  • TuscanA;A 12% A;G 38% G;G 51%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs13208776 is a SNP in the SPARC related modular calcium binding 2 SMOC2 gene. A genome-wide association study (GWAS) of generalized vitiligo in 32 distantly related affected patients from a remote Romanian village identified rs13208776 as highly associated with the disorder, at an odds ratio of 7.445 (CI: 3.5-15.3, p=8x10e-8) and a population attributable risk of 28.

Source and license

Adapted from rs13208776 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.