rs1327328

A SNP on chromosome 13. Its most notable genotype is G;G: normal

Gene
None listed
Location
Chr 1389,750,579 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
38%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.014% of people
  2. A;GNot ratednormalTypical · 0.046% of people
  3. A;ABad1.7x increased risk for multiple sclerosisTypical · 0.040% of people

SNPedia records rs1327328 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 14% A;G 46% A;A 40%
  • European ancestry (Utah)G;G 18% A;G 49% A;A 34%
  • Han Chinese (Beijing)G;G 6% A;G 43% A;A 51%
  • Japanese (Tokyo)G;G 5% A;G 34% A;A 61%
  • Yoruba (Nigeria)G;G 21% A;G 47% A;A 32%
  • African ancestry (Southwest US)G;G 18% A;G 63% A;A 19%
  • Chinese (Denver)G;G 5% A;G 39% A;A 57%
  • Gujarati IndianG;G 8% A;G 46% A;A 47%
  • Luhya (Kenya)G;G 19% A;G 48% A;A 33%
  • Mexican ancestry (Los Angeles)G;G 16% A;G 37% A;A 47%
  • Maasai (Kenya)G;G 19% A;G 47% A;A 34%
  • TuscanG;G 20% A;G 50% A;A 30%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1327328 is a SNP on chromosome 13. In a study of two cohorts (Spanish and American multiple sclerosis patients, each numbering several hundred), rs1327328 was one of eight SNPs associated with increased risk for multiple sclerosis. The odds ratio was 1.7 (CI: 1.2 - 2.5, p = 0.0042).

Source and license

Adapted from rs1327328 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.