rs1333048

A SNP on chromosome 9. Its most notable genotype is C;C: 1.5x increased coronary artery disease risk; 2x increased periodontitis risk

Gene
None listed
Location
Chr 922,125,348 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.033% of people
  2. A;CBad1.3x increased coronary artery disease riskWorth knowing · 2.048% of people
  3. C;CMost notableBad1.5x increased coronary artery disease risk; 2x increased periodontitis riskWorth knowing · 2.118% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 33% A;C 48% C;C 18%
  • European ancestry (Utah)A;A 28% A;C 50% C;C 22%
  • Han Chinese (Beijing)A;A 23% A;C 53% C;C 23%
  • Japanese (Tokyo)A;A 24% A;C 47% C;C 29%
  • Yoruba (Nigeria)A;A 58% A;C 37% C;C 5%
  • African ancestry (Southwest US)A;A 35% A;C 56% C;C 9%
  • Chinese (Denver)A;A 29% A;C 44% C;C 27%
  • Gujarati IndianA;A 25% A;C 55% C;C 21%
  • Luhya (Kenya)A;A 51% A;C 42% C;C 7%
  • Mexican ancestry (Los Angeles)A;A 21% A;C 55% C;C 24%
  • Maasai (Kenya)A;A 53% A;C 40% C;C 6%
  • TuscanA;A 19% A;C 53% C;C 28%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1333048 increases susceptibility to coronary artery disease 1.30 times for heterozygotes (AC) and 1.54 times for homozygotes (CC) Study Draws Genetic Link Between Gum, Cardiovascular Disease rs1333048 2x risk for periodontitis and a confirmation of coronary heart disease

C;C

2x increased risk of periodontitis and coronary heart disease as discussed at 23andMe blog

Source and license

Adapted from rs1333048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.