rs1334512
A SNP in the CD36 gene on chromosome 7. Its most notable genotype is G;G: 0.37x decreased risk for severe malaria
- Gene
- CD36
- Location
- Chr 780,638,588 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 27%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableGood0.37x decreased risk for severe malaria
- G;TGooddecreased risk for severe malaria
- T;TNot ratednormal
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 120 words
rs1334512, also known as -53, is a SNP in the CD36 molecule (thrombospondin receptor) CD36 gene. A study of 552 individuals in India found a protective association between the rs1334512(T) allele and the (T;T) genotype related to severe malaria; (T;T) homozgyotes had a 0.37x (p = 0.004)decreased risk compared to (G;G) homozygotes.7thspace.com Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.
Source and license
Adapted from rs1334512 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.