rs13361189

A SNP on chromosome 5. Its most notable genotype is C;C: 2.6x increased risk for Crohn's disease

Gene
None listed
Location
Chr 5150,843,825 (GRCh38)
Highest magnitude
2.6Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad2.6x increased risk for Crohn's diseaseWorth knowing · 2.611% of people
  2. C;TBad1.3x increased risk for Crohn's diseaseMinor · 1.336% of people
  3. T;TGoodnormalTypical · 0.053% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 11% C;T 36% T;T 53%
  • European ancestry (Utah)C;C 0% C;T 7% T;T 93%
  • Han Chinese (Beijing)C;C 17% C;T 48% T;T 35%
  • Japanese (Tokyo)C;C 17% C;T 42% T;T 41%
  • Yoruba (Nigeria)C;C 24% C;T 53% T;T 23%
  • African ancestry (Southwest US)C;C 18% C;T 48% T;T 34%
  • Gujarati IndianC;C 2% C;T 25% T;T 73%
  • Luhya (Kenya)C;C 18% C;T 41% T;T 40%
  • Mexican ancestry (Los Angeles)C;C 3% C;T 24% T;T 72%
  • Maasai (Kenya)C;C 9% C;T 44% T;T 47%
  • TuscanC;C 1% C;T 25% T;T 74%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs13361189 is a SNP in the IRGM gene. A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16). 23andMe blog Each copy of a C at rs13361189 increases a person's risk of developing Crohn's disease 1.33 times compared to someone with two copies of a T

Source and license

Adapted from rs13361189 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.