rs13376333

A SNP in the KCNN3 gene on chromosome 1. Its most notable genotype is T;T: ~2x higher risk of atrial fibrillation

Gene
KCNN3
Location
Chr 1154,841,877 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNo summary available.Typical · 0.063% of people
  2. C;TBad1.5x higher risk of atrial fibrillationMinor · 1.530% of people
  3. T;TMost notableBad~2x higher risk of atrial fibrillationWorth knowing · 2.07% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 63% C;T 30% T;T 7%
  • European ancestry (Utah)C;C 47% C;T 39% T;T 14%
  • Han Chinese (Beijing)C;C 96% C;T 4% T;T 0%
  • Japanese (Tokyo)C;C 99% C;T <1% T;T 0%
  • Yoruba (Nigeria)C;C 44% C;T 47% T;T 9%
  • African ancestry (Southwest US)C;C 46% C;T 44% T;T 11%
  • Chinese (Denver)C;C 93% C;T 7% T;T 0%
  • Gujarati IndianC;C 63% C;T 33% T;T 4%
  • Luhya (Kenya)C;C 46% C;T 40% T;T 14%
  • Mexican ancestry (Los Angeles)C;C 72% C;T 26% T;T 2%
  • Maasai (Kenya)C;C 28% C;T 53% T;T 19%
  • TuscanC;C 54% C;T 37% T;T 9%

Conditions, medicines and genes

Other KCNN3 SNPs

All KCNN3 SNPs

Notes

From SNPedia

Notes

news atrial fibrillation rs13376333 in KCNN3, with an odds ratio (OR) of 1.5 per copy of rs13376333(T); CI: 1.40&#8211;1.64, p = 1.83 &#215; 10e-21. spitoon

Source and license

Adapted from rs13376333 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.