rs1344706

rs1344706 is a SNP in the ZNF804A gene, and it is probably the first SNP to have been reported as achieving genome-wide significance for psychosis. Reviews the literature, and concludes that rs1344706 is "robustly, if modestly" associated with increased risk for schizophrenia. A genome-wide association study of schizophrenia (479 cases, 2,937 controls) followed by additional testing and a meta-analysis concluded that the strongest evidence for association was around ZNF804A (rs1344706; p = 1.61 x 10e-7) and that the finding was strengthened when the affected phenotype included bipolar disorder (p = 9.96 x 10e-9). Executive function, neural circuitry, and genetic mechanisms in schizophrenia. Apoptotic engulfment pathway and schizophrenia. Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint. Expanding the range of ZNF804A variants conferring risk of psychosis. Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia? ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia. ZNF804A may be associated with executive control of attention. Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population. Evidence of sex-modulated association of ZNF804A with schizophrenia. Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms. Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia. Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia. ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2. The effects of psychosis risk variants on brain connectivity: a review. Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.