rs1375144

A SNP in the DPP10 gene on chromosome 2. Its most notable genotype is G;G: 1.59x increased risk of developing bipolar disorder (one study)

Gene
DPP10
Location
Chr 2115,483,610 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.59x increased risk of developing bipolar disorder (one study)Minor · 1.534% of people
  2. A;GBad1.32x increased risk of developing bipolar disorder (one study)Minor · 1.346% of people
  3. C;CNot ratedNo summary available.Typical · 0.00% of people
  4. A;AGoodNormal risk of developing bipolar disorderMinor · 1.020% of people

SNPedia records rs1375144 on the minus strand: (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 34% A;G 46% C;C 0% A;A 20%
  • European ancestry (Utah)G;G 9% A;G 41% C;C 0% A;A 50%
  • Han Chinese (Beijing)G;G 47% A;G 39% C;C 0% A;A 14%
  • Japanese (Tokyo)G;G 46% A;G 47% C;C 0% A;A 6%
  • Yoruba (Nigeria)G;G 40% A;G 52% C;C 0% A;A 8%
  • African ancestry (Southwest US)G;G 49% A;G 33% C;C 0% A;A 18%
  • Chinese (Denver)G;G 43% A;G 49% C;C 0% A;A 8%
  • Gujarati IndianG;G 21% A;G 58% C;C 0% A;A 21%
  • Luhya (Kenya)G;G 50% A;G 43% C;C 0% A;A 7%
  • Mexican ancestry (Los Angeles)G;G 26% A;G 50% C;C 0% A;A 24%
  • Maasai (Kenya)G;G 32% A;G 51% C;C 0% A;A 17%
  • TuscanG;G 9% A;G 39% C;C 0% A;A 52%

Conditions, medicines and genes

Other DPP10 SNPs

All DPP10 SNPs

Notes

From SNPedia

Notes

rs1375144, a SNP in the DPP10 gene, has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (C) ; the odds ratio associated with heterozygotes is 1.32 (CI 1.07-1.63), and for homozygotes, 1.59 (CI 1.29-1.96). [Note: the 2009 citation below did not see a statistically significant difference between cases and controls for this allele in their study.] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

Source and license

Adapted from rs1375144 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.