rs137852946

A SNP in the PKHD1 gene on chromosome 6. Its most notable genotype is T;T: possible polycystic kidney disease

Gene
PKHD1
Location
Chr 652,024,589 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadpossible polycystic kidney diseaseVery important · 6.0
  2. C;TBadcarrier of a possible polycystic kidney disease alleleImportant · 3.0
  3. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs137852946 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other PKHD1 SNPs

All PKHD1 SNPs

Notes

From SNPedia

Notes

T;T

It is unclear if this risk allele (A) has been seen leading to polycystic kidney disease (when present in homozygous or compound heterozygous form) in more than one patient. Please feel free to contact SNPedia if you have additional information about this allele.

C;T

It is unclear if this risk allele (T) has been seen leading to polycystic kidney disease (when present in homozygous or compound heterozygous form) in more than one patient. Please feel free to contact SNPedia if you have additional information about this allele.

Source and license

Adapted from rs137852946 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.