rs137854604
A SNP in the SCN5A gene on chromosome 3. Its most notable genotype is A;G: possibility of idiopathic ventricular fibrillation
- Gene
- SCN5A
- Location
- Chr 338,551,243 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadpossibility of idiopathic ventricular fibrillation
- A;ABadpossibility of idiopathic ventricular fibrillation
SNPedia records rs137854604 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SCN5A SNPs
- rs137854606A;CBrugada SyndromeVery important
- rs137854612C;TBrugada SyndromeVery important
- rs137854615A;GBrugada SyndromeVery important
- rs137854620C;TBrugada SyndromeVery important
- rs199473058C;TBrugada SyndromeVery important
- rs199473083C;TBrugada SyndromeVery important
- rs199473225A;GBrugada SyndromeVery important
- rs199473249C;GBrugada SyndromeVery important
Notes
From SNPedia
Show notes, about 160 words
A publication has reported that the minor (and quite rare) T allele of rs137854604 was seen in a 39-year-old Japanese patient who was admitted to the hospital for recurrent syncope and suffered an episode of spontaneous ventricular fibrillation while hospitalized. The patient did not have typical ECG findings of Brugada syndrome. This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.
A;G
This genotype includes one SCN5A gene mutation that has been reported - in a single publication - to be associated with idiopathic ventricular fibrillation in patients without typical ECG findings of Brugada syndrome.
A;A
This genotype includes one SCN5A gene mutation that has been reported - in a single publication - to be associated with idiopathic ventricular fibrillation in patients without typical ECG findings of Brugada syndrome.
Source and license
Adapted from rs137854604 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.