rs138042437

A SNP in the CASC19 gene on chromosome 8. Its most notable genotype is A;G: Moderately higher (2-4 fold?) risk for prostate cancer

Gene
CASC19
Location
Chr 8127,196,124 (GRCh38)
Highest magnitude
3.5Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.0
  2. A;GMost notableBadModerately higher (2-4 fold?) risk for prostate cancerImportant · 3.5

On SNPedia: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 200 words

rs138042437 appears to mark a haplotype on chromosome 8 associated with increased risk for prostate cancer, based on a GWAS study of 2511 (unrelated) familial prostate cancer cases. In this cohort, the odds ratio for rs138042437 was 13.3 (CI: 5.4-23.7, p=1.7x10e-8), and an additional test for an excess number of affected carriers among relatives exhibited strong evidence for co-segregation of this variant with the disease (p = 8.5e-11). The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of chromosome 8q24.21 containing the minor alleles of three SNPs: rs183373024, rs188140481 (which was in perfect linkage with rs138042437), and this SNP, rs138042437. The authors of state that due to sampling sizes, "the magnitude of the estimated effect size for (rs138042437) is likely over-stated"; it appears to be more in line with previous OR estimates of around 2. There was no association between this marker and how aggressive the prostate cancer was in carriers, and at this time, the functional basis of the association between the rare haplotype identified and prostate cancer is unclear.

A;G

see discussion at rs138042437

Source and license

Adapted from rs138042437 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.