rs138924661
A SNP in the DGKE gene on chromosome 17. Its most notable genotype is A;A: Nephrotic syndrome type 7
- Gene
- DGKE
- Location
- Chr 1756,848,773 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadNephrotic syndrome type 7
- A;GBadCarrier of nephrotic syndrome mutation; possible effects?
- G;GGoodcommon in clinvar
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Notes
aka c.966G>A, p.Trp322Ter, W322X or W322* ClinVar indicated "likely pathogenic" for atypical hemolytic uremic syndrome, also known as nephrotic syndrome type 7, listed in OMIM as a recessively inherited condition; in , this variant appears to have some effect even if inherited in only one copy (see paper for discussion).
A;A
see discussion and links via main rs-page
A;G
Presumably unaffected in absence of a second DGKE gene mutation, however, see potential effects discussed in article cited in text on main rs-page.
Source and license
Adapted from rs138924661 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.