rs140068132

A SNP on chromosome 6. Its most notable genotype is A;G: lower risk for breast cancer

Gene
None listed
Location
Chr 6151,633,699 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormal/commonTypical · 0.0
  2. A;GMost notableGoodlower risk for breast cancerWorth knowing · 2.2
  3. G;GGoodlower risk for breast cancerWorth knowing · 2.2

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 160 words

A GWAS study looking at breast cancer in Latina women (~3,000 patients and 8,000 unaffected women) concludes that women with the minor (rarer) form of this SNP, rs140068132, have a significantly lower risk for breast cancer, especially for the estrogen receptor negative form of the disease. The odds ratio in general is 0.60 (CI: 0.53-0.67, p=9 × 10e-18); for estrogen receptor negative or positive disease it is 0.34 (CI: 0.21-0.54) and 0.63 (CI: 0.49-0.80), respectively. The minor allele of rs140068132 is also associated with lower mammographic breast density, which is known to have a lower risk for breast cancer (p=0.001).

A;G

The (G) allele of this SNP, rs140068132, is found primarily in Latin (indigenous american) populations and has been associated with lower risk for breast cancer.

G;G

The (G) allele of this SNP, rs140068132, is found primarily in Latin (indigenous american) populations and has been associated with lower risk for breast cancer.

Source and license

Adapted from rs140068132 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.