rs1417066

A SNP in the LOC102723886 gene on chromosome 1. Its most notable genotype is G;G: risk of osteoarthritis

Gene
LOC102723886
Location
Chr 1219,500,486 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadrisk of osteoarthritisMinor · 1.050% of people
  2. A;GBadslightly increased risk of osteoarthritisMinor · 1.035% of people

SNPedia records rs1417066 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 50% A;G 35%
  • European ancestry (Utah)G;G 19% A;G 50%
  • Han Chinese (Beijing)G;G 53% A;G 45%
  • Japanese (Tokyo)G;G 54% A;G 37%
  • Yoruba (Nigeria)G;G 93% A;G 8%
  • African ancestry (Southwest US)G;G 54% A;G 42%
  • Chinese (Denver)G;G 60% A;G 30%
  • Gujarati IndianG;G 16% A;G 47%
  • Luhya (Kenya)G;G 75% A;G 23%
  • Mexican ancestry (Los Angeles)G;G 40% A;G 47%
  • Maasai (Kenya)G;G 68% A;G 23%
  • TuscanG;G 23% A;G 38%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A 2012 large study of osteoarthritis was replicated in 7473 cases and 42,938 controls. The meta-analysis (prior to replication) found approximately 1.12x risk of osteoarthritis for minor allele of rs1417066 (as shown in table ST4, appendix, p. 76), but its significance was p=3·90 E-06 and it did not reach the minimum for genome-wide significance at (p=5·0×10−8).

G;G

see text at rs1417066

Source and license

Adapted from rs1417066 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.