rs1433099
A SNP in the LDLR gene on chromosome 19. Its most notable genotype is T;T: common in clinvar
- Gene
- LDLR
- Location
- Chr 1911,131,982 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 34%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1433099 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 19%
- European ancestry (Utah)T;T 7%
- Han Chinese (Beijing)T;T 7%
- Japanese (Tokyo)T;T 6%
- Yoruba (Nigeria)T;T 42%
- African ancestry (Southwest US)T;T 39%
- Chinese (Denver)T;T 6%
- Gujarati IndianT;T 12%
- Luhya (Kenya)T;T 41%
- Mexican ancestry (Los Angeles)T;T 2%
- Maasai (Kenya)T;T 35%
- TuscanT;T 9%
Related
Other LDLR SNPs
- rs121908027-;-familial hypercholesterolemiaVery important
- rs5933C;GFamilial HypercholesterolemiaVery important
- rs2228671A;CFamilial HypercholesterolemiaVery important
- rs2569548C;TFamilial HypercholesterolemiaVery important
- rs11547917A;CFamilial HypercholesterolemiaVery important
- rs13306512A;CFamilial HypercholesterolemiaVery important
- rs13306515A;CFamilial HypercholesterolemiaVery important
- rs28941776A;GFamilial HypercholesterolemiaVery important
Source and license
Adapted from rs1433099 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.