rs1434536

A SNP in the BMPR1B gene on chromosome 4. Its most notable genotype is T;T: 1.94x increased breast cancer risk

Gene
BMPR1B
Location
Chr 495,154,814 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.94x increased breast cancer riskWorth knowing · 2.016% of people
  2. C;TBad1.29x increased breast cancer riskMinor · 1.345% of people
  3. C;CGoodnormalTypical · 0.040% of people

SNPedia records rs1434536 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 16% C;T 45% C;C 40%
  • European ancestry (Utah)T;T 25% C;T 57% C;C 19%
  • Han Chinese (Beijing)T;T 15% C;T 50% C;C 36%
  • Japanese (Tokyo)T;T 13% C;T 46% C;C 41%
  • Yoruba (Nigeria)T;T 1% C;T 36% C;C 63%
  • African ancestry (Southwest US)T;T 2% C;T 40% C;C 58%
  • Chinese (Denver)T;T 21% C;T 39% C;C 39%
  • Gujarati IndianT;T 21% C;T 45% C;C 35%
  • Luhya (Kenya)T;T 2% C;T 33% C;C 65%
  • Mexican ancestry (Los Angeles)T;T 29% C;T 50% C;C 21%
  • Maasai (Kenya)T;T 8% C;T 51% C;C 42%
  • TuscanT;T 36% C;T 47% C;C 18%

Conditions, medicines and genes

Other BMPR1B SNPs

All BMPR1B SNPs

Notes

From SNPedia

Notes

rs1434536 is a SNP reported to potentially represent a miR-125b binding site. A study of 459 probands from a breast cancer affected sibling pair cohort were recruited from the ECOG study, and in conjunction with 1,145 patient samples from the CGEMS study, led to the conclusion that rs1434536 was associated with increased risk for breast cancer. The odds ratios for rs1434536(A;G) and (A;A) individuals were 1.29 (CI: 0.95-1.74) and 1.94 (CI: 1.40-2.71), respectively (p=1.6x10e-4). A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.

Source and license

Adapted from rs1434536 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.