rs1450425

A SNP in the LOXHD1 gene on chromosome 18. Its most notable genotype is C;T: benign most likely

Gene
LOXHD1
Location
Chr 1846,529,070 (GRCh38)
Highest magnitude
0.5Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.017% of people
  2. C;TMost notableGoodbenign most likelyTypical · 0.543% of people
  3. C;CGoodbenign most likelyTypical · 0.539% of people

SNPedia records rs1450425 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 17% C;T 43% C;C 39%
  • European ancestry (Utah)T;T 3% C;T 41% C;C 57%
  • Han Chinese (Beijing)T;T 20% C;T 52% C;C 29%
  • Japanese (Tokyo)T;T 15% C;T 38% C;C 47%
  • Yoruba (Nigeria)T;T 31% C;T 44% C;C 25%
  • African ancestry (Southwest US)T;T 9% C;T 58% C;C 33%
  • Chinese (Denver)T;T 21% C;T 47% C;C 32%
  • Gujarati IndianT;T 15% C;T 34% C;C 52%
  • Luhya (Kenya)T;T 27% C;T 52% C;C 21%
  • Mexican ancestry (Los Angeles)T;T 16% C;T 33% C;C 52%
  • Maasai (Kenya)T;T 23% C;T 46% C;C 31%
  • TuscanT;T 13% C;T 33% C;C 54%

Source and license

Adapted from rs1450425 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.