rs1467465

A SNP in the C1orf38 gene on chromosome 1. Its most notable genotype is G;G: slightly reduced breast cancer odds?

Gene
C1orf38
Location
Chr 127,884,892 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedslightly reduced breast cancer odds?Typical · 0.038% of people
  2. A;GNot ratedslightly reduced breast cancer odds?Typical · 0.042% of people
  3. A;ANot ratednormalTypical · 0.020% of people

SNPedia records rs1467465 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 38% A;G 42% A;A 20%
  • European ancestry (Utah)G;G 49% A;G 39% A;A 12%
  • Han Chinese (Beijing)G;G 50% A;G 38% A;A 12%
  • Japanese (Tokyo)G;G 33% A;G 41% A;A 27%
  • Yoruba (Nigeria)G;G 22% A;G 43% A;A 35%
  • African ancestry (Southwest US)G;G 23% A;G 53% A;A 25%
  • Chinese (Denver)G;G 39% A;G 49% A;A 13%
  • Gujarati IndianG;G 47% A;G 41% A;A 13%
  • Luhya (Kenya)G;G 20% A;G 46% A;A 34%
  • Mexican ancestry (Los Angeles)G;G 69% A;G 26% A;A 5%
  • Maasai (Kenya)G;G 26% A;G 40% A;A 34%
  • TuscanG;G 46% A;G 43% A;A 11%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A study of 300 breast cancer cases in Germany concluded that the rs1467465(C) allele might have some protective effect.

Source and license

Adapted from rs1467465 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.