rs1495741

A SNP on chromosome 8. Its most notable genotype is A;A: NAT2 slow metabolizer (predicted)

Gene
None listed
Location
Chr 818,415,371 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadNAT2 slow metabolizer (predicted)Worth knowing · 2.042% of people
  2. A;GGoodNAT2 intermediate metabolizer (predicted)Worth knowing · 2.041% of people
  3. G;GGoodNAT2 rapid metabolizer (predicted)Worth knowing · 2.017% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 42% A;G 41% G;G 17%
  • European ancestry (Utah)A;A 53% A;G 36% G;G 11%
  • Han Chinese (Beijing)A;A 18% A;G 47% G;G 36%
  • Japanese (Tokyo)A;A 19% A;G 39% G;G 43%
  • Yoruba (Nigeria)A;A 29% A;G 52% G;G 19%
  • African ancestry (Southwest US)A;A 44% A;G 40% G;G 16%
  • Chinese (Denver)A;A 20% A;G 51% G;G 29%
  • Gujarati IndianA;A 58% A;G 37% G;G 5%
  • Luhya (Kenya)A;A 45% A;G 45% G;G 11%
  • Mexican ancestry (Los Angeles)A;A 47% A;G 47% G;G 7%
  • Maasai (Kenya)A;A 68% A;G 28% G;G 5%
  • TuscanA;A 59% A;G 32% G;G 9%

Conditions, medicines and genes

Notes

From SNPedia

Notes

With 99% sensitivity and 95% specificity, at least in Caucasian populations, rs1495741 is reported to classify the NAT2 phenotype of an individual; it therefore is a candidate to replace the 7-SNP panel used in genosets such as gs138, gs139, and gs140. The rs1495741(A;A), (A;G) and (G;G) genotypes predicted slow, intermediate, and rapid NAT2 acetylation phenotypes, respectively.

A;A

Predicted to be a NAT2 slow metabolizer.

A;G

see discussion at rs1495741

G;G

see discussion at rs1495741

Source and license

Adapted from rs1495741 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.