rs1522305

A SNP in the PAH gene on chromosome 12. Its most notable genotype is C;C: normal

Gene
PAH
Location
Chr 12102,886,978 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.03% of people
  2. C;GNot ratednormalTypical · 0.026% of people
  3. G;GNot ratedslightly increased risk for schizophreniaTypical · 0.071% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 3% C;G 26% G;G 71%
  • European ancestry (Utah)C;C 3% C;G 28% G;G 69%
  • Han Chinese (Beijing)C;C 0% C;G 9% G;G 91%
  • Japanese (Tokyo)C;C 0% C;G 14% G;G 86%
  • Yoruba (Nigeria)C;C 4% C;G 34% G;G 62%
  • African ancestry (Southwest US)C;C 4% C;G 32% G;G 65%
  • Chinese (Denver)C;C <1% C;G 13% G;G 86%
  • Gujarati IndianC;C 1% C;G 22% G;G 77%
  • Luhya (Kenya)C;C 4% C;G 37% G;G 59%
  • Mexican ancestry (Los Angeles)C;C 7% C;G 50% G;G 43%
  • Maasai (Kenya)C;C 6% C;G 31% G;G 63%
  • TuscanC;C 0% C;G 20% G;G 80%

Conditions, medicines and genes

Other PAH SNPs

All PAH SNPs

Notes

From SNPedia

Notes

rs1522305 is a SNP in the phenylalanine hydroxylase (PAH) gene. A study of Caucasian cohorts, Bulgarian families, and African American families concluded that the more common rs1522305(G) allele was associated in the first two populations with increased risk for schizophrenia.

Source and license

Adapted from rs1522305 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.