rs1529927

A SNP in the SLC12A3 gene on chromosome 16. Its most notable genotype is G;G: common in complete genomics

Gene
SLC12A3
Location
Chr 1656,870,675 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
2%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in complete genomicsTypical · 0.096% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 96%
  • European ancestry (Utah)G;G 83%
  • Han Chinese (Beijing)G;G 100%
  • Japanese (Tokyo)G;G 100%
  • Yoruba (Nigeria)G;G 100%

Conditions, medicines and genes

Other SLC12A3 SNPs

All SLC12A3 SNPs

Notes

From SNPedia

Notes

This SNP is cited in US patent 10,465,246 (2019), where one of the claims is prescribing a hydrochlorothiazide to a patient as a first line therapy (for high blood pressure), without a beta blocker and without a vasodilator, if the patient carries a rs1529927(T). Note that this appears to be an error in the patent as written and as issued; the authors likely should have written rs1529927(C).

Source and license

Adapted from rs1529927 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.