rs1537415
A SNP in the GLT6D1 gene on chromosome 9. Its most notable genotype is C;C: 2x increased risk for periodontitis
- Gene
- GLT6D1
- Location
- Chr 9135,637,876 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 31%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GNot ratednormal
- C;GBad1.6x increased risk for periodontitis
- C;CMost notableBad2x increased risk for periodontitis
SNPedia records rs1537415 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 48% C;G 42% C;C 10%
- European ancestry (Utah)G;G 33% C;G 49% C;C 19%
- Han Chinese (Beijing)G;G 67% C;G 29% C;C 4%
- Japanese (Tokyo)G;G 59% C;G 37% C;C 4%
- Yoruba (Nigeria)G;G 52% C;G 43% C;C 5%
- African ancestry (Southwest US)G;G 42% C;G 47% C;C 11%
- Chinese (Denver)G;G 63% C;G 31% C;C 6%
- Gujarati IndianG;G 55% C;G 35% C;C 10%
- Luhya (Kenya)G;G 36% C;G 52% C;C 12%
- Mexican ancestry (Los Angeles)G;G 52% C;G 41% C;C 7%
- Maasai (Kenya)G;G 44% C;G 46% C;C 10%
- TuscanG;G 28% C;G 47% C;C 26%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs1537415 is an intronic SNP in the glycosyltransferase 6 domain containing 1 GLT6D1 gene. In a combined study of 1,758 Dutch and German subjects, the rs1537415(G) allele was associated with increased risk for periodontitis, at an odds ratio of 1.59 (CI: 1.36-1.86, p=5.5x10e-9).
Source and license
Adapted from rs1537415 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.