rs1566439

A SNP in the NLRC5 gene on chromosome 16. Its most notable genotype is G;G: associated with higher HDL cholesterol

Gene
NLRC5
Location
Chr 1656,990,750 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
41%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedassociated with higher HDL cholesterolWorth knowing · 2.00% of people
  2. A;GNot ratedassociated with higher HDL cholesterolWorth knowing · 2.00% of people

SNPedia records rs1566439 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 0% A;G 0%
  • European ancestry (Utah)G;G 0% A;G 0%
  • Han Chinese (Beijing)G;G 0% A;G 0%
  • Japanese (Tokyo)G;G 0% A;G 0%
  • Yoruba (Nigeria)G;G 0% A;G 0%
  • African ancestry (Southwest US)G;G 0% A;G 0%
  • Chinese (Denver)G;G 0% A;G 0%
  • Gujarati IndianG;G 0% A;G 0%
  • Luhya (Kenya)G;G 0% A;G 0%
  • Mexican ancestry (Los Angeles)G;G 0% A;G 0%
  • Maasai (Kenya)G;G 0% A;G 0%
  • TuscanG;G 0% A;G 0%

Conditions, medicines and genes

Other NLRC5 SNPs

All NLRC5 SNPs

Notes

From SNPedia

Notes

C allele is associated with 0.96mg/dl increase in HDL cholesterol (good cholesterol).

Source and license

Adapted from rs1566439 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.