rs1566734

A SNP in the PTPRJ gene on chromosome 11. Its most notable genotype is C;C: somatic mutation found once in a colon cancer

Gene
PTPRJ
Location
Chr 1148,123,823 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratedNo summary available.Typical · 0.00% of people
  2. C;CMost notableBadsomatic mutation found once in a colon cancerMinor · 1.04% of people
  3. A;CBadSomatic mutation, cancer associatedTypical · 0.527% of people
  4. A;AGoodcommon in clinvarTypical · 0.069% of people

SNPedia records rs1566734 on the minus strand: (A;A), (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 0% C;C 4% A;C 27% A;A 69%
  • European ancestry (Utah)T;T 0% C;C 2% A;C 22% A;A 76%
  • Han Chinese (Beijing)T;T 0% C;C 7% A;C 26% A;A 68%
  • Japanese (Tokyo)T;T 0% C;C 4% A;C 41% A;A 55%
  • Yoruba (Nigeria)T;T 0% C;C <1% A;C 16% A;A 84%
  • African ancestry (Southwest US)T;T 0% C;C 4% A;C 28% A;A 68%
  • Chinese (Denver)T;T 0% C;C 6% A;C 41% A;A 53%
  • Gujarati IndianT;T 0% C;C 7% A;C 37% A;A 56%
  • Luhya (Kenya)T;T 0% C;C 0% A;C 16% A;A 85%
  • Mexican ancestry (Los Angeles)T;T 0% C;C 2% A;C 21% A;A 78%
  • Maasai (Kenya)T;T 0% C;C 1% A;C 17% A;A 82%
  • TuscanT;T 0% C;C 7% A;C 38% A;A 55%

Other PTPRJ SNPs

All PTPRJ SNPs

Notes

From SNPedia

Notes

NOTE: the OMIM entry cited below refers to a somatic mutation, not a germline SNP PTPRJ haplotypes and colorectal cancer risk.

C;C

this is *not* reported to be a germline mutation of the type reported to increase one's colon cancer risk

Source and license

Adapted from rs1566734 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.