rs1573496

rs1573496 is a SNP in the ADH7 alcohol dehydrogenase 7 gene. A study of over 3,800 cases of "upper aerodigestive" cancers (mouth/throat, voice box, and esophageal cancers) concluded that the rs1573496(G) allele has a protective effect. Carriers of this allele had a 0.68x (decreased; p=10 -9 ) risk of having one of these cancer types. A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. The data in this paper, makes it seem that (G;G) was much more common. This is inconsistent with the HapMap frequencies, suggesting the sequence may have been flipped. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. Evidence of positive selection on a class I ADH locus. Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population. Esophageal Cancer: Preliminary Research Larynx Cancer Oral and Throat Cancers