rs157582

A SNP in the TOMM40 gene on chromosome 19. Its most notable genotype is T;T: Weaker memory performance

Gene
TOMM40
Location
Chr 1944,892,962 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadWeaker memory performanceWorth knowing · 2.110% of people
  2. C;TNot ratedAverage memory performanceMinor · 1.538% of people
  3. C;CGoodStronger memory performanceWorth knowing · 2.152% of people

SNPedia records rs157582 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 10% C;T 38% C;C 52%
  • European ancestry (Utah)T;T 6% C;T 35% C;C 58%
  • Han Chinese (Beijing)T;T <1% C;T 40% C;C 59%
  • Japanese (Tokyo)T;T 3% C;T 33% C;C 65%
  • Yoruba (Nigeria)T;T 22% C;T 54% C;C 24%
  • African ancestry (Southwest US)T;T 18% C;T 46% C;C 37%
  • Chinese (Denver)T;T 5% C;T 23% C;C 73%
  • Gujarati IndianT;T 6% C;T 23% C;C 71%
  • Luhya (Kenya)T;T 30% C;T 52% C;C 18%
  • Mexican ancestry (Los Angeles)T;T 3% C;T 36% C;C 60%
  • Maasai (Kenya)T;T 19% C;T 47% C;C 35%
  • TuscanT;T 2% C;T 29% C;C 69%

Other TOMM40 SNPs

All TOMM40 SNPs

Source and license

Adapted from rs157582 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.