rs16139

A SNP in the NPY gene on chromosome 7. Its most notable genotype is T;T: common in clinvar

Gene
NPY
Location
Chr 724,285,260 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in clinvarTypical · 0.091% of people

SNPedia records rs16139 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 6 HapMap populations.

  • AverageT;T 91%
  • European ancestry (Utah)T;T 88%
  • Han Chinese (Beijing)T;T 100%
  • Japanese (Tokyo)T;T 99%
  • Yoruba (Nigeria)T;T 99%
  • African ancestry (Southwest US)T;T 98%
  • Maasai (Kenya)T;T 60%

Other NPY SNPs

All NPY SNPs

Notes

From SNPedia

Notes

Medical sequencing at the extremes of human body mass. Genetic variation in human NPY expression affects stress response and emotion. Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. A systematic meta-analysis of genetic association studies for diabetic retinopathy. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. Poor replication of candidate genes for major depressive disorder using genome-wide association data.

Source and license

Adapted from rs16139 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.