rs1625579
A SNP in the MIR137HG gene on chromosome 1. Its most notable genotype is G;G.
- Gene
- MIR137HG
- Location
- Chr 198,037,378 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1625579 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 4%
- European ancestry (Utah)G;G 3%
- Han Chinese (Beijing)G;G 0%
- Japanese (Tokyo)G;G <1%
- Yoruba (Nigeria)G;G 10%
- African ancestry (Southwest US)G;G 9%
- Chinese (Denver)G;G 0%
- Gujarati IndianG;G 7%
- Luhya (Kenya)G;G 9%
- Mexican ancestry (Los Angeles)G;G 2%
- Maasai (Kenya)G;G 3%
- TuscanG;G 5%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
schizophrenia, p = 1.6 x 10^-11, top hit in a rather large combined sample of (stage 1) 21,856 Europeans and (stage 2, replication) 29,839 independent individuals, see also this post on the Schizophrenia Research Forum Per the above reference, this SNP is located within an intron of miR-137 / MIR137 (on Wikipedia). Four other additional loci containing predictive targets of this microRNA also passed the threshold for genome-wide significance.. potentially suggesting some involvement of miR-137 mediated activity in the disease. Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia.
Source and license
Adapted from rs1625579 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.