rs16260

A SNP in the CDH1 gene on chromosome 16. Its most notable genotype is A;A: 2.6x increased risk of prostate cancer

Gene
CDH1
Location
Chr 1668,737,131 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2.6x increased risk of prostate cancerTypical · 0.04% of people
  2. A;CBad1.5-1.7x increased risk of prostate cancerTypical · 0.033% of people
  3. C;CGoodnormalTypical · 0.063% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 4% A;C 33% C;C 63%
  • European ancestry (Utah)A;A 4% A;C 47% C;C 49%
  • Han Chinese (Beijing)A;A 5% A;C 40% C;C 55%
  • Japanese (Tokyo)A;A 4% A;C 31% C;C 65%
  • Yoruba (Nigeria)A;A 2% A;C 26% C;C 72%
  • African ancestry (Southwest US)A;A 2% A;C 18% C;C 81%
  • Chinese (Denver)A;A 8% A;C 36% C;C 56%
  • Gujarati IndianA;A 2% A;C 45% C;C 54%
  • Luhya (Kenya)A;A 0% A;C 22% C;C 78%
  • Mexican ancestry (Los Angeles)A;A 7% A;C 29% C;C 64%
  • Maasai (Kenya)A;A 2% A;C 24% C;C 74%
  • TuscanA;A 2% A;C 48% C;C 50%

Conditions, medicines and genes

Other CDH1 SNPs

All CDH1 SNPs

Notes

From SNPedia

Notes

PMID 14961571, PMID 16189707 rs16260 (A) SNP located in the promoter region of the E-cadherin CDH1 gene is associated with increased risk of hereditary prostate cancer. The effect appears to be additive, in that compared to the rs16260(C;C) homozygotes, the rs16260(A;C) heterozygotes are at about a 1.5 - 1.7 fold increased risk, and the rs16260(A;A) homozygotes are at about a 2.6 fold increased risk. * see also OMIM 192090.0018

Source and license

Adapted from rs16260 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.