rs1667394

A SNP in the HERC2 gene on chromosome 15. Its most notable genotype is T;T: blond hair & blue eyes is 4x more likely

Gene
HERC2
Location
Chr 1528,285,036 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedblond hair & blue eyes is 4x more likelyMinor · 1.517% of people
  2. C;CNot rateddarker skin, eye and hair color is more likelyMinor · 1.554% of people

SNPedia records rs1667394 on the minus strand: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 17% C;C 54%
  • European ancestry (Utah)T;T 72% C;C <1%
  • Han Chinese (Beijing)T;T 5% C;C 58%
  • Japanese (Tokyo)T;T 7% C;C 66%
  • Yoruba (Nigeria)T;T 0% C;C 91%
  • African ancestry (Southwest US)T;T 4% C;C 60%
  • Chinese (Denver)T;T 7% C;C 55%
  • Gujarati IndianT;T 14% C;C 43%
  • Luhya (Kenya)T;T 0% C;C 95%
  • Mexican ancestry (Los Angeles)T;T 40% C;C 21%
  • Maasai (Kenya)T;T <1% C;C 86%
  • TuscanT;T 35% C;C 20%

Other HERC2 SNPs

All HERC2 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs1667394 increases susceptibility to Blond rather than brown hair 4.94 times for carriers of the A allele rs1667394 increases susceptibility to Blue rather than brown eyes 29.43 times for carriers of the A allele rs1667394 increases susceptibility to Blue rather than green eyes 6.74 times for carriers of the A allele For green versus blue eye color rs12913832 in OCA2/HERC2 has a score of 51.5 and an estimated allelic OR of 8.43 . The SNP rs1667394 in this same region has an estimated OR of (4.85&#8211;10.06).

T;T

but nearby rs12913832 seems to be a more reliable predictor.

Source and license

Adapted from rs1667394 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.