rs167771

A SNP in the DRD3 gene on chromosome 3. Its most notable genotype is G;G.

Gene
DRD3
Location
Chr 3114,157,428 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Minor · 1.039% of people
  2. G;GMost notableNot ratedNo summary available.Minor · 1.127% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 39% G;G 27%
  • European ancestry (Utah)A;A 67% G;G 4%
  • Han Chinese (Beijing)A;A 63% G;G <1%
  • Japanese (Tokyo)A;A 72% G;G 4%
  • Yoruba (Nigeria)A;A 2% G;G 76%
  • African ancestry (Southwest US)A;A 12% G;G 39%
  • Chinese (Denver)A;A 66% G;G 4%
  • Gujarati IndianA;A 33% G;G 16%
  • Luhya (Kenya)A;A 0% G;G 86%
  • Mexican ancestry (Los Angeles)A;A 45% G;G 7%
  • Maasai (Kenya)A;A 9% G;G 55%
  • TuscanA;A 61% G;G 5%

Conditions, medicines and genes

Other DRD3 SNPs

All DRD3 SNPs

Notes

From SNPedia

Notes

rs167771 was significantly associated with autism spectrum disorder in a study of 144 patients. G allele associated with increased extra-pyramidal symptom risk as a result of risperidone treatment in a study of 321 psychiatric inpatients (81 presenting with EPS and 189 without)

A;A

Possibly more "Insistence on Sameness" on ADI-R test.ncbi.nlm.nih.gov Possibly increased FTND nicotine dependence.ncbi.nlm.nih.gov

G;G

Increased extra-pyramidal symptom risk as a result of risperidone treatment in a study of 321 psychiatric inpatients. Possibly less "Insistence on Sameness" in ADI-R test.

Source and license

Adapted from rs167771 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.