rs16847548

A SNP on chromosome 1. Its most notable genotype is C;C: 2.6x increased risk for sudden cardiac death in Caucasians

Gene
None listed
Location
Chr 1162,065,484 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad2.6x increased risk for sudden cardiac death in CaucasiansWorth knowing · 2.510% of people
  2. C;TBad1.3x increased risk for sudden cardiac death in CaucasiansMinor · 1.339% of people
  3. T;TNot ratednormalTypical · 0.050% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 10% C;T 39% T;T 50%
  • European ancestry (Utah)C;C 0% C;T 27% T;T 73%
  • Han Chinese (Beijing)C;C 11% C;T 56% T;T 33%
  • Japanese (Tokyo)C;C 24% C;T 42% T;T 33%
  • Yoruba (Nigeria)C;C 6% C;T 33% T;T 60%

Notes

From SNPedia

Notes

rs16847548 and rs16856785 strongly associated with QT interval Based on a large study of 19,000+ adults, SNPs rs10494366, rs4657139 and rs16847548 were significantly associated with adjusted QT interval in whites but not in African-Americans. The relative hazard of sudden cardiac death (SCD) associated with each rs16847548(C) allele was 1.31 (CI: 1.10 - 1.56, p=0.002). rs12567209 was also independently associated with SCD in whites (relative hazard 0.57, CI: 0.39 - 0.83, p=0.003).

Source and license

Adapted from rs16847548 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.