rs16891982(G;G)

Generally European; Light skin; Possibly an increased risk of melanoma

Magnitude
1.1Minor
Repute
Not rated
Frequency
24%Average of 4 populations
On SNPedia
rs16891982(G;G)
Gene
SLC45A2

Frequency

Share of people with G;G in each HapMap population.

  • European ancestry (Utah)97%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs16891982

  1. C;CGoodgenerally non-European, but if European, 7x more likely to have black hairMinor · 1.174% of people
  2. C;GMost notableNot ratedif European, 7x more likely to have black hairWorth knowing · 2.01% of people

All about rs16891982

Notes

From SNPedia

This SNP is associated with skin, hair, and eye colour, and risk of melanoma. Individuals with the G;G genotype are generally of European descent and have fair skin. In a population-based case-control study investigating a number of pigmentation-related SNPs and their correlation with cutaneous malignant melanoma (CMM) in a Caucasian Australian population, rs16891982 (variant F374L) was found to be associated with odds ratios of 3.44, 2.86, 1.68, and 1.68 for all study subjects (1,738 CMM cases and 4,517 controls); subjects with northern European ancestry (1,438 cases and 3,098 controls); northern European subjects adjusted for hair, eye, and skin colour; and northern European subjects adjusted for the MC1R genotype, respectively (p<0.001 for all).

Source and license

Adapted from rs16891982(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.