rs16953002(G;G)

Slightly lower risk of melanoma in individuals with low BMI

Magnitude
1.0Minor
Repute
Good
Frequency
64%Average of 11 populations
On SNPedia
rs16953002(G;G)
Gene
FTO

Frequency

Share of people with G;G in each HapMap population.

  • Mexican ancestry (Los Angeles)85%
  • Luhya (Kenya)80%
  • European ancestry (Utah)74%
  • Maasai (Kenya)71%
  • Yoruba (Nigeria)67%
  • Gujarati Indian65%
  • Tuscan65%
  • African ancestry (Southwest US)56%
  • Japanese (Tokyo)53%
  • Han Chinese (Beijing)42%
  • Chinese (Denver)42%

Other genotypes of rs16953002

  1. A;AMost notableBad1.32x increased risk of melanoma in those with low BMIMinor · 1.55% of people
  2. A;GBad1.16x increased risk of melanoma in indiiduals with low BMIMinor · 1.232% of people

All about rs16953002

Notes

From SNPedia

Highly significant, replicated studies, p=3.6e-12. Risk allele A appears to represent a greater risk in those with low BMI, which is plausible due to the known role of FTO in obesity. This SNP is in intron 8, whereas BMI SNP's are usually in intron 1. The association was much stronger for those in the lowest quartile of BMI (1.66 per A allele risk) vs those in the other 3 quartiles (1.03 per A allele risk - no longer statistically significant). Risk for those in higher 3 quartiles of BMI is likely not substantially affected.

Source and license

Adapted from rs16953002(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.