rs17077540

A SNP in the LOC643542 gene on chromosome 18. Its most notable genotype is A;G: 1.6x major depressive disorder risk

Gene
LOC643542
Location
Chr 1867,618,042 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in complete genomicsTypical · 0.082% of people
  2. A;GMost notableBad1.6x major depressive disorder riskWorth knowing · 2.117% of people
  3. G;GBad1.6x major depressive disorder riskWorth knowing · 2.1<1% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 82% A;G 17% G;G <1%
  • European ancestry (Utah)A;A 85% A;G 15% G;G 0%
  • Han Chinese (Beijing)A;A 82% A;G 18% G;G 0%
  • Japanese (Tokyo)A;A 73% A;G 24% G;G 2%
  • Yoruba (Nigeria)A;A 89% A;G 11% G;G 0%

Source and license

Adapted from rs17077540 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.