rs17185536
A SNP on chromosome 6. Its most notable genotype is T;T: slight increase in risk for ED in men
- Gene
- None listed
- Location
- Chr 6100,173,055 (GRCh38)
- Highest magnitude
- 1.3Minor
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TBadslight increase in risk for ED in males
- T;TMost notableBadslight increase in risk for ED in men
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 76% C;T 20% T;T 4%
- European ancestry (Utah)C;C 52% C;T 42% T;T 6%
- Han Chinese (Beijing)C;C 98% C;T 2% T;T 0%
- Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
- Yoruba (Nigeria)C;C 57% C;T 36% T;T 8%
Notes
From SNPedia
Notes
rs17185536 is a SNP located on chromosome 6 near the SIM1 gene that was significantly associated with a slight increase in risk of erectile dysfunction (ED) in men (odds ratio ~1.25, =p=6.8 × 10e−14). The study was based on 36,649 men from four race/ethnicity groups (non-Hispanic whites, Hispanic/Latinos, East Asians, and African Americans) and replication across 200,000+ UK BioBank samples. The risk associated with rs17185536 appeared independent of known risk factors for ED such as weight, smoking and diabetes, but note also that it explained a very small percentage (1.6%) of heritability of the condition.
C;T
see text on main rs-page
T;T
see text on main rs-page
Source and license
Adapted from rs17185536 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.