rs17376328

A SNP in the CLCN6 gene on chromosome 1. Its most notable genotype is A;A: lower blood pressure

Gene
CLCN6
Location
Chr 111,816,605 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedlower blood pressureTypical · 0.0<1% of people
  2. A;GNot ratedlower blood pressureTypical · 0.05% of people
  3. G;GGoodnormalTypical · 0.095% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A <1% A;G 5% G;G 95%
  • European ancestry (Utah)A;A 0% A;G 14% G;G 86%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 5% G;G 95%
  • African ancestry (Southwest US)A;A 0% A;G 2% G;G 98%
  • Chinese (Denver)A;A 0% A;G <1% G;G 99%
  • Gujarati IndianA;A 0% A;G 7% G;G 93%
  • Luhya (Kenya)A;A <1% A;G 5% G;G 95%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 2% G;G 98%
  • Maasai (Kenya)A;A 2% A;G 10% G;G 89%
  • TuscanA;A 1% A;G 7% G;G 92%

Conditions, medicines and genes

Other CLCN6 SNPs

All CLCN6 SNPs

Notes

From SNPedia

Notes

A study of ~15,000 Europeans found that increased circulating natriuretic peptide and thus lower blood pressure and hypertension were associated with SNPs rs17376328(A), rs5068, rs198358(C), rs632793(G) 23andMe blog

Source and license

Adapted from rs17376328 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.