rs174548

A SNP in the FADS1 gene on chromosome 11. Its most notable genotype is C;C: highest phosphatidylcholine values

Gene
FADS1
Location
Chr 1161,803,876 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedhighest phosphatidylcholine valuesTypical · 0.052% of people
  2. C;GNot ratedintermediate phosphatidylcholine valuesTypical · 0.036% of people
  3. G;GNot ratedlowest phosphatidylcholine valuesTypical · 0.012% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 52% C;G 36% G;G 12%
  • European ancestry (Utah)C;C 48% C;G 44% G;G 8%
  • Han Chinese (Beijing)C;C 42% C;G 44% G;G 15%
  • Japanese (Tokyo)C;C 47% C;G 43% G;G 11%
  • Yoruba (Nigeria)C;C 75% C;G 22% G;G 3%
  • African ancestry (Southwest US)C;C 63% C;G 37% G;G 0%
  • Chinese (Denver)C;C 30% C;G 41% G;G 28%
  • Gujarati IndianC;C 82% C;G 18% G;G 0%
  • Luhya (Kenya)C;C 66% C;G 31% G;G 3%
  • Mexican ancestry (Los Angeles)C;C 14% C;G 40% G;G 47%
  • Maasai (Kenya)C;C 46% C;G 45% G;G 9%
  • TuscanC;C 60% C;G 35% G;G 5%

Notes

From SNPedia

Notes

FADS1 codes for an enzyme involved in fatty acid unsaturation and the FADS1 gene SNP rs174548 seems to explain as much as ten percent of the variance in the metabolism of some glycerophospholipids. news A study of metabolite concentrations in the blood of 284 adult males from Southern Germany determined that several SNPs were associated either directly with a metabolite range or with a ratio of metabolites. The rarer rs174548(G) allele was associated with decreased phosphatidylcholine values. 295px|thumb|left|

Source and license

Adapted from rs174548 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.