rs1746048

A SNP on chromosome 10. Its most notable genotype is T;T: 0.85 decreased risk for coronary heart disease

Gene
None listed
Location
Chr 1044,280,376 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBad1.03 increased risk for coronary heart diseaseMinor · 1.345% of people
  2. C;TGood0.94 decreased risk for coronary heart diseaseMinor · 1.841% of people
  3. T;TMost notableGood0.85 decreased risk for coronary heart diseaseWorth knowing · 2.014% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 45% C;T 41% T;T 14%
  • European ancestry (Utah)C;C 71% C;T 29% T;T 0%
  • Han Chinese (Beijing)C;C 44% C;T 41% T;T 15%
  • Japanese (Tokyo)C;C 49% C;T 41% T;T 11%
  • Yoruba (Nigeria)C;C 16% C;T 56% T;T 28%
  • African ancestry (Southwest US)C;C 30% C;T 46% T;T 25%
  • Chinese (Denver)C;C 47% C;T 41% T;T 12%
  • Gujarati IndianC;C 44% C;T 51% T;T 6%
  • Luhya (Kenya)C;C 25% C;T 40% T;T 35%
  • Mexican ancestry (Los Angeles)C;C 75% C;T 23% T;T 2%
  • Maasai (Kenya)C;C 25% C;T 53% T;T 22%
  • TuscanC;C 72% C;T 26% T;T 3%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

23andMe blog coronary artery disease and heart attack SNP Risk Version Effect *rs646776 T 1.19 *rs17465637 C 1.14 *rs1746048 C 1.17 *rs6725887 C 1.17 *rs11206510 T 1.15 *rs3184504 T 1.13 *rs2306374 C 1.15 *rs3782886 C 1.44 Coronary Heart Disease

Source and license

Adapted from rs1746048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.