rs17487223

A SNP in the CHRNB4 gene on chromosome 15. Its most notable genotype is T;T: 1.28x lung cancer risk

Gene
CHRNB4
Location
Chr 1578,631,645 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.075% of people
  2. C;TBadHigher lung cancer risk?Worth knowing · 2.020% of people
  3. T;TMost notableBad1.28x lung cancer riskWorth knowing · 2.55% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 6 HapMap populations.

  • AverageC;C 75% C;T 20% T;T 5%
  • European ancestry (Utah)C;C 35% C;T 45% T;T 20%
  • Han Chinese (Beijing)C;C 93% C;T 7% T;T 0%
  • Japanese (Tokyo)C;C 96% C;T 5% T;T 0%
  • Yoruba (Nigeria)C;C 87% C;T 13% T;T 0%
  • Chinese (Denver)C;C 92% C;T 8% T;T 0%
  • Maasai (Kenya)C;C 48% C;T 43% T;T 10%

Other CHRNB4 SNPs

All CHRNB4 SNPs

Notes

From SNPedia

Notes

rs17487223 increases susceptibility to Lung cancer 1.28 times for carriers of the T allele plos Risk Factors for Age-Dependent Nicotine Addiction

Source and license

Adapted from rs17487223 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.